TY - JOUR AU - Zhang, Junjie AU - Baig, Sameer AU - Wong, Alexander AU - Haider, Masoom A. AU - Khalvati, Farzad PY - 2016/10/03 Y2 - 2024/03/28 TI - A Local ROI-specific Atlas-based Segmentation of Prostate Gland and Transitional Zone in Diffusion MRI JF - Journal of Computational Vision and Imaging Systems JA - J. Comp. Vis. Imag. Sys. VL - 2 IS - 1 SE - Articles DO - 10.15353/vsnl.v2i1.113 UR - https://openjournals.uwaterloo.ca/index.php/vsl/article/view/113 SP - AB - Segmentation of prostate and related anatomic structure, such as transitional zone, in medical images facilitates prostate cancer detection, as well as a number of other clinical practices. In this paper, we propose a semi-automatic local ROI-specific atlas-based segmentation (LABS) method to segment prostate gland and transitional zone in diffusion magnetic resonance images. Inspired by a sequential registration-based segmentation method, the proposed method further reduces the amount of user intervention and focuses on the vicinity of prostate for atlas matching and atlas-to-target registration by specifying the bounding boxes of prostate gland on key slices of volume images. We evaluated the method on an atlas database with the 100 cases by performing a leave-one-out study. Our proposed method produced favorable outcomes with an average Dice similarity coefficient of 0.85±0.03 for prostate gland and 0.77±0.06 for transitional zone segmentations, which indicates the effectiveness of the proposed method and its potential to be used in relevant clinical applications. ER -